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Vidyya, from the Sanskrit "vaidya," a practitioner who has come to understand the science of life.

Volume 2 Published - 14:00 UTC    08:00 EST    30-January-2001      
Issue 30 Next Update - 14:00 UTC 08:00 EST    31-January-2001      

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Back To Vidyya Study Underway To Test Anti-Inflammatory Medicines For Prevention Of Alzheimer's Disease

Medicines May Unlock the Mystery of Alzheimer's Disease

Alzheimer's disease affects up to 4 million Americans. If no cure is found, that number could double in 20 years as baby boomers age. On 30 January, the Alzheimer's Disease Anti-inflammatory Prevention Trial, or ADAPT, will begin to test whether anti-inflammatory pain relievers could prevent this degenerative brain disease.

The study, sponsored by The National Institute on Aging with additional support from the manufacturers of the study drugs, is enrolling participants at four sites across the country: The Johns Hopkins Medical Institutions in Baltimore, The University of Rochester, Boston University School of Medicine, and Sun Health Research Institute in Phoenix.

Researchers have noted that people who regularly take anti-inflammatory medicines seem less likely to develop Alzheimer's disease. The Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT) is a new clinical research study that will test the link between the use of anti-inflammatory medicines and the prevention of Alzheimer's disease.

Patients will be able to participate in this study if they meet the following criteria:

  • 70 or older
  • Biological parent, brother, or sister who has (or had) serious age-related memory loss, dementia, senility, or Alzheimer's disease
  • Have not been diagnosed with dementia, senility, or Alzheimer's disease
  • Live near a site where the study is being conducted
Participants will be asked to:
  • Take an anti-inflammatory medicine, either naproxen (Aleve®) or celecoxib (Celebrex®), or a placebo (sugar pill) daily for several years
  • Go to the local study site for a medical evaluation (cognitive and physical tests) three times in the first year of the study and twice a year after that
  • Participate in a telephone interview twice a year

  • All study medicines will be provided free of charge

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Editor: Susan K. Boyer, RN
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