What is epilepsy?
Epilepsy is a neurological disorder
that affects people in every country throughout the world. Epilepsy is also one
of the oldest conditions known to mankind. It is characterized by a tendency to
recurrent seizures and it defined by two or more unprovoked seizures.
The belief widely held in many countries is that a person
with epilepsy is seized by a supernatural force or power. This ancient belief is
reflected in the name of the disorder – the word "epilepsy" being
derived from the Greek word "epilambanein" which means "to seize
or attack". We now know, however, that seizures are the result of sudden,
usually brief, excessive electrical discharges in a group of brain cells (neurones)
and that different parts of the brain can be the site of such discharges. The
clinical manifestations of seizures will therefore vary and depend on where in
the brain the disturbance first starts and how far it spreads. Transient
symptoms can occur, such as loss of awareness or consciousness and disturbances
of movement, sensation (including vision, hearing and taste), mood or mental
Seizures may vary from the briefest lapses of attention or
muscle jerks to severe and prolonged convulsions. They may also vary in frequency, from less than one a year
to several per day. Seizures are classified according to where in the brain they
arise, for instance:
- Partial or focal seizures
These seizures arise from an electric discharge of one or
more localised areas of the brain regardless of whether the seizure is
secondarily generalized. Depending on their type, they may or may not impair
consciousness. Whether seizures are partial or focal, they begin in a localized
area of the brain, but then may spread to the whole brain causing a generalized
The electrical discharge which leads to these seizures
involves the whole brain and may cause loss of consciousness and/or muscle
contractions or stiffness. They include what used to be known as "grand
mal" convulsion and also the brief "petit mal" absence of
This is a state in which a person has frequent seizures
without recovery of consciousness between each episode. It is a dangerous state
and if not treated may lead to brain damage or death.
It is unclear why particular seizures occur at a particular
age or time and not at other ages or times. Provocative factors, however, are
recognized in some patients. For example, certain flashing lights (discos,
television, video games etc.), over-breathing, over-hydration, loss of sleep,
and/or emotional and physical stress, may stimulate seizures. Although these are
not causes of epilepsy, they may influence the timing and frequency of seizures.
Different epileptic syndromes are based on the age of onset,
the type of seizure, the presence or absence of detectable brain disease and
genetic background. However, medical science is only at an early stage in
understanding these different types.
EPIDEMIOLOGY: PREVALENCE, INCIDENCE AND MORTALITY OF EPILEPSY
Epilepsy knows no geographical, racial or social boundaries.
It occurs in men and women and can begin at any age, but is most frequently
diagnosed in infancy, childhood, adolescence and old age. Anyone can be affected
by seizures. In fact, up to 5% of the world’s population may have a single
seizure at some time in their lives, but a diagnosis of epilepsy is reserved for
those who have recurring seizures, at least two unprovoked ones.
The prevalence of a disorder is the proportion of a
population with that disorder at a given point in time. From many studies around
the world it has
been estimated that the mean prevalence of active epilepsy (i.e. continuing
seizures or the need for treatment) is approximately 8.2 per 1,000 of the
general population. However, this may be an underestimate as some studies in
developing countries (such as Colombia, Ecuador, India, Liberia, Nigeria,
Panama, United Republic of Tanzania and Venezuela) suggest a prevalence of more
than 10 per 1,000.
- Thus, it is likely that around 50 million people in the world have
epilepsy at any one time. The lifetime prevalence of epilepsy (i.e. the
number of people presently in the world who have epilepsy now or have had it
in the past or will experience it in the future) is approximately 100
The incidence of a disorder is the number of new cases at a
given time. Studies in developed countries suggest an annual incidence of
epilepsy of approximately 50 per 100,000 of the general population. However,
studies in developing countries suggest that this figure is nearly double that
at 100 per 100,000.
One of the main reasons for the higher incidence of epilepsy
in developing countries is the higher risk of experiencing a condition which can
lead to permanent brain damage. These conditions include 1neurocysticercosis,
meningitis, malaria, pre and perinatal complications and malnutrition.
Epilepsy is associated with an increased risk of mortality.
Death may be related to:
- An underlying brain disease, such as a tumour or infection;
- Seizures in dangerous circumstances, leading to drowning, burns or head
injury, for example;
- Sudden and unexplained causes, or a possible respiratory or
cardio-respiratory arrest during a seizure;
Whilst studies on this subject are sparse, epilepsy-related
deaths in young adults in the UK, for example, are 3 times higher than standard
age-related mortality rates.
ETIOLOGY OF EPILEPSY
Epilepsy is often, but not always, the result of an
underlying brain disease. Any type of brain disease can cause epilepsy, but not
all people with the same brain disease will have epilepsy. In view of the fact
that only a proportion of people who have a brain disease experience seizures as a
symptom of that disease, it is suspected that those who do have such symptomatic
seizures are more vulnerable due to biochemical/neurotransmitter reasons.
- There are still many people for whom the cause of their epilepsy cannot,
as yet, be identified. In such cases, the theory most commonly accepted is
that this epilepsy is the result of an imbalance of certain chemicals in the
brain (especially chemical messengers known as neurotransmitters) causing
them to have a low convulsive threshold.
- Children and adolescents are more likely to have epilepsy of unknown or
genetic origin. The older the patient, the more likely it is that the cause
is an underlying brain disease, such as a brain tumour or cerebrovascular
disease, or is the result of head injury.
- Trauma and brain infection can cause epilepsy at any age, and as mentioned
previously may account for a higher incidence of epilepsy in developing
countries. For example, a common cause in Latin America is
neurocysticercosis cysts on the brain caused by tapeworm infection, while in
Africa, malaria and meningitis are common causes, and in India
neurocysticercosis and tuberculosis often lead to epilepsy.
- Febrile illness of any kind can trigger seizures in young children. About
3% of children who have febrile convulsions go on to develop epilepsy in
TREATMENT AND PROGNOSIS
Recent studies in both developed and developing countries
have shown that up to 70% of newly diagnosed children and adults with epilepsy
can be successfully treated (i.e, their seizures can be completely controlled
for several years) with anti-epileptic drugs. After 2-5 years of successful
treatment, drugs can be withdrawn in about 70% of children and 60% of adults
- However, up to 30% of people may not respond to drug therapy. A factor
which leads to worse prognosis is the presence of an underlying brain
- Partial seizures, especially if associated with a brain disease, are more
difficult to control than generalized seizures.
- Secondary seizures- not epilepsy- such as those related to an acute,
short-lasting brain disease, may run a self-limiting course. However, a
significant proportion of people will develop established epilepsy.
- For economic and social reasons, 3 out of 4 people with epilepsy do not
receive treatment at all. Most of these people live in developing countries.
- Epilepsy is one of the most common neurological disorder and has no age,
racial, social, sexual or geographical boundaries.
- Up to 5% of people in the world may have at least one seizure in their
- At any one point in time, 50 million people have epilepsy, especially in
childhood, adolescence and old age.
- Epilepsy can have profound social, physical and psychological consequences.
- In up to 70% of people, epilepsy responds to treatment, but in developing
countries, three-fourths of people with epilepsy may not receive the
treatment they need.