Designed to determine if current methods used in cancer screening can effectively decrease morbidity (illness) or mortality (death) from cancers of the prostate, lung, colon/rectum, and ovary (PLCO), the PLCO Cancer Screening Trial, sponsored by the National Cancer Institute, is actively seeking participants.
The screening methods being tested in the trial include prostate (prostate-specific-antigen or PSA for short), digital-rectal-exam (DRE), lung (chest x-ray), colorectal (flexible sigmoidoscopy), and ovary (CA125 blood test, palpation of ovaries i.e., pelvic exam).
The PLCO Trial will enroll almost 150,000 individuals, who are between 55-74 years old, nationwide. Men and women will be equally represented. Half of the trial participants will be randomly (by chance) assigned to the intervention (screening) arm and half will be assigned to the control arm (usual medical care).
For more information, the web sites for the national level PLCO and each of the 10 screening centers are as follows:
National Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial
Georgetown University Medical Center - Lombardi Cancer Research Center, Washington, DC
Henry Ford Health System, Detroit, MI
Marshfield Medical Research and Education Foundation, Marshfield, WI
Pacific Health Research Institute, Honolulu, HI
University of Alabama at Birmingham, Birmingham, AL
University of Colorado Health Sciences Center, Denver, CO
University of Minnesota School of Public Health/Virginia L. Piper Cancer Institute, Minneapolis, MN
University of Pittsburgh Cancer Center, Pittsburgh, PA
University of Utah, Salt Lake City, UT
Washington University School of Medicine, St. Louis, MO
CDC and NCI Join Forces to Increase Recruitment of African-American Men
A joint effort is under way between the Centers for Disease Control and Prevention (CDC) and the NCI to increase and improve recruitment of African-American men in the the PLCO screening trial. Under this joint venture, investigators at the Henry Ford Health System will evaluate the effectiveness of three incrementally different recruitment strategies that have been designed to increase participation rates among older African-American men living in the Detroit, Michigan, area. The investigators will determine the corresponding rise in response rates among African-American men, as well as the costs associated with successfully using each recruitment strategy. Besides the increased participation of minorities in the PLCO trial, investigators think this evaluation will help them plan for similar trials in the future.