Cell cycle kinases as therapeutic targets for cancer
A comprehensive overview that explores the prospects and progress of synthetic inhibitors to target cell cycle kinases in cancer forecasts that “novel compounds with increased potency, improved kinase specificity and favorable drug like properties will soon be available for clinical evaluation.”
Existing Parkinson’s disease drug may fight drug-resistant TB
Existing drugs used in the treatment of Parkinson's disease could be repositioned for use in the treatment of extreme drug-resistant tuberculosis, which kills about 2 million people each year, according to a study led by researchers at the University of California, San Diego. The rise of these strains of TB throughout the world, including industrialized countries, poses a great threat to human health. more
Childhood arthritis: common but preventable consequence of Lyme disease
When left untreated, children infected with Lyme disease can experience many severe complications as a result including arthritis, problems with the heart or central nervous system. more
Predicting the return of prostate cancer: new study betters the odds of success
Cancer experts at Johns Hopkins say a study tracking 774 prostate cancer patients for a median of eight years has shown that a three-way combination of measurements has the best chance yet of predicting disease metastasis. more
Infants should be screened for hip trouble
Developmental hip dysplasia is the most common congenital defect in newborns. The condition occurs when a hip joint is shallow, unstable or when the joint is dislocated. Infants with the condition are often at risk of developing arthritis of the hip as a young adult. A new study published in the July 2009 issue of The Journal of Bone and Joint Surgery (JBJS) finds that screening all infants for hip dysplasia can significantly decrease their chance of developing early arthritis.
Celiac disease four times more common than in 1950s
Celiac disease, an immune system reaction to gluten in the diet, is over four times more common today than it was 50 years ago, according to findings of a Mayo Clinic study published this month in the journal Gastroenterology. more
Certain biomarkers may have limited benefit for predicting cardiovascular events
Use of several older and newer biomarkers appears to offer minimal added benefit in the prediction of cardiovascular events compared to conventional risk factors such as high cholesterol and high blood pressure, according to a study in the July 1 issue of JAMA. more
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