Ketamine reduces suicidality in depressed patients
Drug treatment options for depression can take weeks for the beneficial effects to emerge, which is clearly inadequate for those at immediate risk of suicide. However, intravenous (IV) ketamine, a drug previously used as an anesthetic, has shown rapid antidepressant effects in early trials.
International conference on endothelin
One of the most intriguing developments in recent medical science is the discovery of the human chemical endothelin (ET). Since its detection in 1988, over 22,000 scholarly articles (about 3 per day) have been published on the subject, a new class of drugs has been developed, and 25 Phase I, II and III clinical trails are now underway. more
Males may experience greater physical pain due to lower levels
of a key protein, endothelin
Agonizing physical pain, known as vaso-occlusive pain, can afflict children who have sickle cell disease (SCD). In some cases infants as young as two months of age suffer vaso-occlusive pain so severe that opiate medications and hospitalizations are their only relief. Researchers believe vaso-occlusion is caused by a blockage of the blood vessels that occurs when sickle shaped red cells attempt to pass through the round blood vessels. How vaso-occulsion leads to pain, and its impact on males and females are still unknown. A University of South Carolina research team suggests that a naturally occurring chemical in the body, endothelin (ET), may play a role. more
New type of adult stem cells found in the prostate may be involved in prostate cancer development
A new type of stem cell discovered in the prostate of adult mice can be a source of prostate cancer, according to a new study by researchers at the Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center and NewYork-Presbyterian Hospital. more
Noisy roads increase risk of high blood pressure
Traffic noise raises blood pressure. Researchers writing in BioMed Central's open access journal Environmental Health have found that people exposed to high levels of noise from nearby roads are more likely to report suffering from hypertension.
STD confirmed to be associated with increased risk of prostate cancer
Researchers confirmed previous findings that the sexual transmitted infection known as Trichomonas vaginalis is associated with an increased risk of prostate cancer in a study published online September 9 in the Journal of the National Cancer Institute. more
Virus responsible for deadly brain disease found in MS patients treated with natalizumab
The virus responsible for PML (progressive multifocal leukoencephalopathy), a rare brain disease that typically affects AIDS patients and other individuals with compromised immune systems, has been found to be reactivated in multiple-sclerosis patients being treated with natalizumab (Tysabri). The findings, led by scientists at Beth Israel Deaconess Medical Center (BIDMC), appear in tomorrow's issue of The New England Journal of Medicine (NEJM).
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