Why the MRC didn't fund research that led to the birth of the world's first test tube baby

Thirty-two years ago today, the world's first baby was born after in vitro fertilisation. However, the work that led to the birth of Louise Brown on 25 July 1978 had to be privately funded after the UK's Medical Research Council decided in 1971 against providing the Cambridge physiologist Robert Edwards and the Oldham gynaecologist Patrick Steptoe with long-term financial support. Today, an intriguing paper published in Europe's leading reproductive medicine journal Human Reproduction [1] reveals for the first time the reasoning behind the MRC's much-criticised decision. more  

Study recommends that parents, physicians share decisions in sex development disorder surgery

A shared decision-making process would assist doctors and parents who are facing the extraordinarily complex, challenging and controversial choices presented when infants are born with genetic or anatomical anomalies in sexual development and are being considered for elective corrective surgery, a new research paper suggests. more

Noninvasive MR imaging of blood vessel growth in tumors using nanosized contrast agents

Formation of new blood vessels, also known as angiogenesis, is crucial for sustained tumor growth and cancer metastasis. Recently, clinically available therapies to suppress the growth of these vessels have been available to improve patient survival in some cancer types. Accurate detection and quantification of blood vessel growth using nonsurgical methods would greatly complement current therapies and allow physicians to quickly assess treatment regimens and adjust them as necessary. In the work published in the August issue of Experimental Biology and Medicine, Kessinger and coworkers have incorporated nanotechnology, material science, and the clinical imaging modality MRI, to create a nanosized probe capable of noninvasively visualizing and quantifying the blood vessel growth in tumors in a preclinical model. The work was carried out by Chase Kessinger, as part of his PhD thesis in cancer molecular imaging, working together with Jinming Gao and other colleagues, at the University of Texas Southwestern Medical Center at Dallas. more  

Length of stay in ERs reaches new high, delays in moving admitted patients out of ERs blamed : Nation's emergency physicians predict conditions will continue to deteriorate

Average length of stay in the nation's emergency departments increased to four hours and seven minutes, and the nation's emergency physicians are very concerned about patient safety being jeopardized by long wait times. Press Ganey's Pulse Report 2010, released yesterday, confirms what the American College of Emergency Physicians has reported previously: The recession, high unemployment and insurance losses are increasing pressure on emergency departments and their patients. more

Can we prevent Alzheimer’s disease?  

Will doing crossword puzzles prevent memory loss as we age? Does exercise delay or prevent Alzheimer’s disease? Will adding fish oil to a diet help keep our brains healthy as we age? NIH recently convened a conference to answer these and other questions. The conclusion? Research so far has offered good leads about preventing Alzheimer’s disease and age-related cognitive decline. Still, more research is needed before we can be sure what’s effective. more

Gene pattern spells freedom from medications  

Most patients who’ve received a kidney transplant have to take special drugs—called immunosuppressants—for the rest of their lives. Otherwise, their body’s own immune system will attack and destroy the transplanted organ. more

Einstein receives $4 million to test HPV microbicide

The National Cancer Institute has awarded Albert Einstein College of Medicine of Yeshiva University $4.1 million to test the microbicide Carraguard® against the human papillomavirus (HPV), which causes cervical cancer. The research will evaluate the efficacy of Carraguard®, – a clear gel made from the seaweed derivative carrageenan – in preventing new HPV infections in women. more

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