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US Food And Drug Administration Approves Topamax(R) (Topiramate) Tablets And Sprinkle Capsules As An Adjunctive Treatment For Lennox-Gastaut Syndrome
Adults and children (age 2-16) who suffer from seizures associated with Lennox-Gastaut Syndrome -- a severe, debilitating form of epilepsy -- now have a much-needed new treatment option with the announcement today that the U.S. Food and Drug Administration has approved Topamax(R) (topiramate) tablets and sprinkle capsules as an adjunctive (add-on) treatment for this condition more
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Prescribing Information: Topamax(R) (Topiramate) Tablets And Sprinkle Capsules
Topamax is marketed under various brand names in more than 75 countries and to date, has been used to treat seizures in approximately 825,000 patients worldwide. The FDA first approved Topamax in 1996 as add-on treatment for adults with partial-onset seizures. In July 1999, the drug was the first "new-generation" anti-epileptic drug to be approved to treat partial-onset seizures as adjunctive therapy in children as young as two years old. In October of 1999, Topamax also was approved as add-on treatment for primary, generalized "tonic-clonic" seizures (in which a temporary loss of consciousness and muscle control occurs) in adults and children aged 2-16. more
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AHRQ Report: Diagnosis And Management Of Specific Breast Abnormalities (Summary)
Each year, more than 170,000 women are diagnosed with breast cancer in the United States alone, and it is the most common form of cancer found in women worldwide. The average lifetime risk of breast cancer in a female infant born in the United States in the year 2000 is 12 percent, or one in eight. The most common cause of malpractice litigation is the missed or delayed diagnosis of breast cancer. Clearly, breast disease is a major concern for women, and it has a substantial effect on both individual and societal health care resources. more
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Information For Patients: NINDS Lennox-Gastaut Syndrome Information Page
Lennox-Gastaut syndrome is a severe form of epilepsy (a seizure disorder). It usually develops in children between 1 and 8 years old and is characterized by several types of seizures, developmental delay, and behavioral disturbances such as poor social skills and attention-seeking behavior. Most children with Lennox-Gastaut syndrome experience some degree of impaired intellectual functioning or information processing. The disorder may be caused by brain injury, severe brain infections, genetic brain diseases, or developmental malformations of the brain. more
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Safe Effective Treatment To Stop Seizures Can Be Delivered Outside Of The Hospital
A new study shows that paramedics can safely and effectively treat patients who are suffering from acute and prolonged seizures with injections of benzodiazepines, a mild form of tranquilizers. In 59 percent of patients who received lorazepam, and in 43 percent of patients treated with diazepam, the seizures stopped before they arrived at the emergency department. Conversely, only 21 percent of patients in the placebo group arrived at the hospital seizure free. more
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