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Alcohol Researchers Show "Friendly" Virus Slows HIV Cell Growth
A team of alcohol researchers led by Jack Stapleton, M.D., of the Department of Internal Medicine, University of Iowa College of Medicine and the Iowa City Veterans Affairs Medical Center, report in the 06 September 2001, New England Journal of Medicine, Volume 345, 2001 "Effect of co-infection with GB virus type C (Hepatitis G Virus) on survival of HIV-infected individuals: In vitro co-infection suggests inhibition of HIV replication by GB virus C" that GB virus type C (GBV-C) appears to have retarded the progression of human immunodeficiency virus in a 12-year clinical study of HIV patients. Using an infectious molecular clone of GBV-C, the same team showed in a laboratory study that GBV-C reduces the growth rate of HIV in cultured human T-cells, a form of white blood cells or lymphocytes. more
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A Small Genetic Change Makes Flu Virus Deadly
A tiny change in one of the influenza virus's 10 genes is key to making certain strains of the virus especially virulent to humans, scientists report in the 07 September 2001 issue of Science. This discovery helps explain why an influenza outbreak four years ago in Hong Kong killed an unusually high proportion of the people it infected -- six out of 18, says lead researcher Yoshihiro Kawaoka, DVM, PhD, of the University of Wisconsin-Madison. more
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Updated: Guidelines For The Use Of Antiretroviral Agents In HIV-Infected Adults And Adolescents
This "living guideline" regarding the use of antiretroviral agents in HIV-infected adults and adolescents has been updated as of 13 August 2001 to include the latest considerations for the initiation of drug therapy for HIV-infected individuals and information on what happens when that therapy is interrupted. The availability of an increasing number of antiretroviral agents and the rapid evolution of new information has introduced extraordinary complexity into the treatment of HIV-infected persons. This guideline should help. more
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Structure Of Integrin Alpha-V-Beta-3 Revealed - Protein Key To The Next Generation of Cancer Drugs
After five years of transatlantic collaboration, researchers of Merck KGaA and the Massachusetts General Hospital (MGH) have solved, for the first time ever, the full structure of an integrin receptor. This key protein plays a major role in the control of biological processes and diseases, ranging from cancer to restenosis, osteoporosis, rheumatism and inflammation. The important findings of the research team, which will appear in Science Magazine and were published today on the Science Express website. more
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Two Asthma Maintenance Therapies Compared In New Study
A study published today in the American Journal of Respiratory Critical Care Medicine is the first to compare the safety and efficacy of new Advair(TM) Diskus(R) 100/50 (fluticasone propionate 100 mcg and salmeterol 50 mcg inhalation powder) twice daily with Singulair(R) 10mg (montelukast) once daily as initial maintenance therapy. more
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