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Study Pinpoints Mechanism Behind Tamoxifen Side Effect
Researchers at Dana-Farber Cancer Institute have identified the underlying mechanism that causes one
of the unwanted side effects of tamoxifen. The study, published in the March 29 issue of Science, may help researchers home in
on new medications that, like tamoxifen, reduce the risk of certain types of breast cancer, but do not carry tamoxifen's
potentially dangerous downside. more
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Prescribing Information: Nolvadex (Tamoxifen Citrate)
Nolvadex (tamoxifen citrate) Tablets work by blocking estrogen. In breast tissue, Nolvadex is an
antiestrogen. An antiestrogen or estrogen blocker works by blocking estrogen in breast tissue. While estrogen may not actually
cause breast cancer, it may stimulate its growth, feeding the cancer. With estrogen blocked, the cancer cells that need it may not
grow at all. In other words, antiestrogens may keep cancer from developing in the breast. Get full prescribing information for this
product in today's issue of Vidyya. more
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More Evidence Of Tamoxifen's Benefit For Women At Risk Of Breast Cancer
Preliminary results from a large international trial, the International Breast Cancer Intervention Study
(IBIS), provide additional evidence that the drug tamoxifen (Nolvadex) can reduce the incidence of breast cancer in women at
increased risk for the disease. Women taking tamoxifen experienced one third fewer breast cancers than women who took a
placebo (dummy pill), researchers announced on March 20, 2002, at the 3rd European Breast Cancer Conference in
Barcelona, Spain. more
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Gene Enhances Effects Of Estrogen On Good Cholesterol
A genetic variant seems to determine how well women's good cholesterol responds to estrogen
therapy, reports David Herrington, M.D., from Wake Forest University Baptist Medical Center in this week's New England
Journal of Medicine. The finding could help doctors identify women most likely to gain a heart benefit from hormone
therapy. more
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Expanded Web Site Will Help Primary Care Physicians Diagnose Smallpox, Anthrax, And Other
Bioterrorism-Related Infections
A Web site sponsored by the Agency for Healthcare Research and Quality (AHRQ) is being
expanded to help 265,000 primary care physicians across the country learn how to diagnose and treat rare infections and
exposures to bioterrorist agents such as smallpox and anthrax. more
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