Vidyya Medical News Service
Volume 5 Issue 20 Published - 14:00 UTC 08:00 EST 20-Jan-2003 Next Update - 14:00 UTC 08:00 EST 21-Jan-2003
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Researchers find a genetic connection in Sudden Infant Death Syndrome (SIDS)
Researchers at Rush-Presbyterian-St. Luke's Medical Center have found evidence supporting a relationship between SIDS and the 5-HTT gene in both African-Americans and Caucasians. They found a significant positive association between SIDS and the L/L genotype, and between SIDS and the 5-HTT L allele, and a negative association between SIDS and the S/S genotype. This information might eventually lead to the identification of infants at risk for SIDS.  more

Sudden infant death syndrome and the child care provider
Child care providers who do not follow current recommendations for infant sleep position and bedding may be at risk for legal action if an infant dies of SIDS while in their care. The purpose of this fact sheet is to educate child care providers about SIDS and its risk factors, as well as to encourage providers to utilize resources offered by the National SIDS and Infant Death Program Support Center.  more


New AHRQ evidence report finds autopsies help to uncover medical diagnostic discrepancies
Autopsies continue to detect clinically important diagnostic discrepancies, according to a new evidence report released today by the Agency for Healthcare Research and Quality. Based on an analysis of more than 50 studies spanning 40 years, researchers estimate that, in U.S. hospitals in the year 2000, the correct cause of death escaped clinical detection in between 8 percent and 23 percent of cases, with as many as 4 percent to 8 percent of all deaths having a diagnostic discrepancy that may have harmed the patient. In addition to clinically missed diagnoses, up to 5 percent of autopsies disclosed clinically unsuspected complications of care. more

Summary evidence report: Autopsy as an outcome and performance measure
The findings of this review have different implications depending on the level of analysis individual clinicians, hospitals, or the health care system as a whole. From the point of view of the individual clinician, the chance that autopsy will reveal important unsuspected diagnoses in a given case remains significant. Moreover, clinicians do not seem able to predict reliably cases in which such findings are more likely to occur. Thus, clinicians have compelling reasons to request autopsies far more often than currently occurs.  more

Acute myeloid leukemia, risk stratification, and bone marrow transplant strategy
For adult patients with acute myeloid leukemia (AML), an evidence-based approach to optimize treatment is proposed based on risk stratification. Findings in a recent study to be published in the February 1, 2003 print issue of the journal Cancer indicate that treatment directed by baseline cytogenetic testing is superior to treating with bone marrow transplant (BMT) or chemotherapy (CT) without regard to those cytogenetic risk factors. CT for low risk AML patients and BMT for intermediate and high-risk patients was associated with greater quality adjusted life years (QALY) than use of BMT or CT alone for all AML patients.  more

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