Vidyya Medical News Service
Volume 5 Issue 345 Published - 14:00 UTC 08:00 EST 11-Dec-2003 Next Update - 14:00 UTC 08:00 EST 12-Dec-2003
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NIH consensus panel confirms effectiveness of total knee replacement: Panel calls for more research into racial, ethnic, and gender disparities
A panel charged with reviewing all of the available evidence on total knee replacement (TKR) today found that for persons suffering from intractable and persistent knee pain and disability, TKR surgery is a safe and cost-effective therapy that restores mobility and alleviates discomfort. Over 20 years of follow-up data indicate that the procedure is successful in the vast majority of patients.  more

Evidence report/technology assessment: Total knee replacement
Total knee arthroplasty is one of the most common orthopedic procedures performed. In 2001 171,335 primary knee replacements and 16,895 revisions were performed. Because these procedures are elective and expensive (Medicare paid approximately $3.2 billion in 2000 for hip and knee joint replacements) and because the prevalence of arthritis is expected to grow substantially as the population ages, these procedures are likely to come under increasing scrutiny.  more


Starting dose of Lexapro as effective as optimally dosed Zoloft in the treatment of depression
The results of a clinical study showed that Lexapro (escitalopram oxalate) is as effective as Zoloft(sertraline hydrochloride). The purpose of the study was to evaluate whether the starting dose of Lexapro, 10 mg per day, could provide comparable efficacy to the full dosing range of Zoloft, 50 200 mg per day. Study results showed that patients receiving a dose of 10 mg per day of Lexapro experienced similar efficacy compared to patients receiving a median dose of Zoloft of 150 mg per day. more

Prescribing information: Lexapro (escitalopram oxalate)
Lexapro is an antidepressant that is the newest member of the family of medications known as selective serotonin reuptake inhibitors (SSRIs). Lexapro was developed by isolating a part of the Celexa (citalopram HBr) molecule, known as an isomer. The resulting medication, Lexapro, can be taken at lower doses.  more

FDA announces comprehensive foods advisory on methylmercury
The Food and Drug Administration's (FDA) Food Advisory Committee (FAC) met on December 10-11, 2003 to receive an update regarding the recommendations made during the July 2002 FAC regarding fish consumption and methylmercury. The revisions have resulted in the first unified FDA and EPA revised advisory concerning all fish and shellfish consumption for populations at risk from exposure to high mercury levels: pregnant women, nursing mothers, women who may become pregnant, and young children. more

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