Vidyya Medical News Service
Volume 5 Issue 52 Published - 14:00 UTC 08:00 EST 21-Feb-2003 Next Update - 14:00 UTC 08:00 EST 22-Feb-2003
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Selegiline hydrochloride may help smokers quit
NIDA-supported researchers from Yale University Transdisciplinary Tobacco Use Research Center (TTURC) have found more evidence that monoamine oxidase-B (MAO-B) inhibitors may be an effective treatment for nicotine addiction. MAO-B is an enzyme that breaks down dopamine. The symptoms of nicotine withdrawal have been associated with a decrease in the concentration of dopamine, so increasing dopamine levels with MAO-B inhibitors may be helpful for the treatment of nicotine addiction.  more

OHSU scientists locate, characterize key hormone involved in appetite control
Researchers at Oregon Health & Science University (OHSU) have identified a key hormone involved in appetite control and demonstrated its effect on the brain. Scientists have shown that the hormone, called ghrelin, activates specialized neurons in the hypothalamus involved in weight regulation. The research involved scientists at several collaborating institutions, including: Yale Medical School, Baylor College of Medicine, the University of Alberta and Lilly Research Laboratories. more


Prescribing information: Eldepryl (Selegiline hydrochloride)
Eldepryl belongs to a class of drugs known as MAO inhibitors. These drugs can interact with certain foods--including aged cheeses and meats, pickled herring, beer, and wine--to cause a life-threatening surge in blood pressure. At the dose recommended for Eldepryl, this interaction is not a problem. But for safety's sake, you may want to watch your diet; and you should never take more Eldepryl than the doctor prescribed.  more

Alcohol researchers identify a genetic basis of pain response
A common genetic variant influences individual responses and adaptation to pain and other stressful stimuli and may underlie vulnerability to many psychiatric and other complex diseases, reports David Goldman, M.D., Chief, Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, and colleagues at NIAAA and the University of Michigan.  more

Quitting smoking offers benefits; unsuccessful attempts may change view of health risk
Researchers from Arizona State University and Indiana University found that after a 6-year period, smokers who succeeded in quitting reported less stress and did not experience increases in negative moods, such as depression or nervousness. Successful quitters also came to view smoking as being less beneficial psychologically and more harmful to their health compared to when they were smokers.  more

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