Vidyya Medical News Service
Volume 6 Issue 158 Published - 14:00 UTC 08:00 EST 6-Jun-2004 Next Update - 14:00 UTC 08:00 EST 7-Jun-2004
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Gene mutation and use of certain antidepressants may decrease effects of breast cancer drug
Researchers from the Johns Hopkins Kimmel Cancer Center, Indiana University and the University of Michigan have found that some women have a gene mutation that may decrease the effectiveness of tamoxifen, a commonly used breast cancer drug. The findings were reported at the 40th annual meeting of the American Society of Clinical Oncology on 5 June and may tell physicians which women might have reduced benefit from tamoxifen therapy. Results also suggest that some frequently prescribed antidepressants may reduce tamoxifen's effects because the antidepressants affect a similar metabolic pathway.  more

Prostate cancer pill may stave off disease and ease pain
Recent clinical studies led by Johns Hopkins Kimmel Cancer Center researchers have found that a drug called atrasentan reduces the risk by 20 percent that cancer will progress in men with advanced hormone-resistant prostate cancer. The results were presented at the 40th Annual American Society of Clinical Oncology (ASCO) meeting in New Orleans. more

Global study shows new breast cancer drug extends patients' overall survival
Breast cancer patients with advanced disease live longer when treated with a new drug, gemcitabine, in combination with paclitaxel, a traditional drug, according to results of a landmark global phase III study presented at the American Society of Clinical Oncology (ASCO) annual meeting.  more


Study finds Velcade major improvement over standard therapy for relapsed multiple myeloma patients
Early results from a major, international Phase III clinical trial decisively show that recurrent multiple myeloma is more effectively treated with the drug bortezomib (trade name: Velcade TM) than with dexamethasone, a drug that for decades has been the standard therapy for relapsed disease, researchers at Dana-Farber Cancer Institute report.  more

When combining new oral anti-cancer agents with standard chemotherapy, timing may be crucial
Timing may be everything when it comes to combining the new-generation oral, molecularly targeted anti-cancer agents with standard chemotherapy drugs, UC Davis Cancer Center researchers reported Saturday at the annual meeting of the American Society of Clinical Oncologists.  more

Late invasion of infected cells into the brain causes HIV dementia say Temple researchers
Dementia in AIDS patients is caused by a large, late invasion of HIV-infected macrophages--large, long-lived cells of the immune system that travel throughout the body and ingest foreign antigens to protect against infection--into the brain, according to researchers at Temple University's Center for Neurovirology and Cancer Biology, debunking a longstanding "Trojan Horse" theory that early infection by macrophages remains latent until the latter stages of AIDS.  more

Patients who broke bones in traumatic accidents frequently suffer from stress disorder
People who have had a traumatic bone break also frequently suffer from Post-traumatic Stress Disorder, researchers at UT Southwestern Medical Center at Dallas have found. more

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