Vidyya Medical News Service
Volume 6 Issue 265 Published - 14:00 UTC 08:00 EST 21-Sep-2004 Next Update - 14:00 UTC 08:00 EST 22-Sep-2004
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Fractures mean broken lives in developing world
Broken bones often mean lifelong disability in the developing world, due to a lack of access to simple, inexpensive initial treatment, says the director of the University of Toronto's international surgery program.  more

Circulating mononuclear cells in the obese found to be in proinflammatory state, contributing to diabetes and heart disease
Endocrinologists from the University at Buffalo are providing one more link in the growing chain of evidence pointing to chronic cellular inflammation as the precursor of heart disease and diabetes.  more

Vanilla may have a future in sickle cell treatment
In addition to its popular role in flavoring ice cream, fudge and cake frosting, vanilla may have a future use as a medicine. Recent laboratory research has strengthened the possibility that a form of vanilla may become a drug to treat sickle cell disease.  more


Researchers eliminate leukemia in mice, demonstrating potential new approach to cancer drug therapy
Scientists at Dana-Farber Cancer Institute have corrected a flaw in cancer cells that lets them evade the normal cell-death process, and as a result they eliminated leukemia cells from mice. With this achievement, the researchers confirm that a key anti-cell-death molecule called BCL-2 is required by many types of cancer cells to survive, and that silencing it with designer drugs may prove to be an effective new avenue for cancer therapy.  more

Intravenous line placement for minor ear surgery in children appears to offer no added benefit
Children who had intravenous (IV) access for ear tube placement surgery spent more time in the operating room and in the hospital and required more pain medication than children who underwent the same procedure without IV access, according to an article in the September issue of The Archives of Otolaryngology Head & Neck Surgery, one of the JAMA/Archives journals.  more

Prion propagation: Avoiding the toxic oligomer
The key to any protein's function is its structure. Improperly folded proteins are normally destroyed. But in a wide range of diseases, including prion (from proteinaceous and infectious) diseases and neurodegenerative diseases like Parkinson disease and Alzheimer disease, amyloid fibrils, or plaques--misshapen proteins that aggregate into characteristic ropelike configurations--accumulate in tissue. When amyloid precursors and prions lose their normal conformation, they acquire the ability to infect their neighbors. Like molecular dominoes, the fall of one malformed protein precipitates the downfall of its neighbors, as one protein after another assumes the misshapen form of the first. Any chance of developing methods to contain the expansionist tendencies of these proteins depends on understanding the mechanism of propagation, an area of active research.  more

More frequent monitoring advised for people with diabetes
A Johns Hopkins study suggests that people with type I and type II diabetes would be well advised to monitor their blood sugar levels more than the usual twice daily to make sure that levels are not elevated over 150 milligrams per deciliter for sustained periods. A research team at Hopkins has added new and detailed evidence of the link between elevated blood sugar levels in people with diabetes and increased risk of developing life-threatening forms of cardiovascular disease - including coronary heart disease, stroke and peripheral artery disease.  more

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