Vidyya Medical News Service
Volume 6 Issue 304 Published - 14:00 UTC 08:00 EST 30-Oct-2004 Next Update - 14:00 UTC 08:00 EST 31-Oct-2004
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Trojan-horse therapy blocks buildup of Alzheimer’s plaques
A potential new therapeutic approach to Alzheimer's disease protects brain cells in culture by drastically reducing the neurotoxic amyloid protein aggregates that are critical to the development of the disease. The treatment involves dispatching a small molecule into the cell to enlist the aid of a larger 'chaperone' protein to block the accumulation of the brain-clogging protein.  more

Research uncovers role of Apolipoprotein E in Alzheimer's disease
A research team has for the first time defined how the protein Apolipoprotein E (ApoE) contributes to both the formation of amyloid brain lesions and the memory loss associated with Alzheimer's disease.  more

Stress impairs thinking via mania-linked enzyme
An errant enzyme linked to bipolar disorder, in the brain's prefrontal cortex, impairs cognition under stress, an animal study shows. The disturbed thinking, impaired judgment, impulsivity, and distractibility seen in mania, a destructive phase of bipolar disorder, may be traceable to overactivity of protein kinase C (PKC), suggests the study, funded by the National Institutes of Health's (NIH) National Institute of Mental Health (NIMH) and National Institute on Aging (NIA), and the Stanley Foundation. It explains how even mild stress can worsen cognitive symptoms, as occurs in bipolar disoder, which affects two million Americans.  more


Some chest pain patients may benefit from more evaluation
New research shows that almost 3 percent of patients who went to hospital emergency rooms with chest pain – but who weren’t initially diagnosed with heart problems – went on to have heart attacks or other heart-related events within a month.  more

Anxiety good for memory recall, bad for solving complex problems
Pre-test jitters make it easier to recall memorized facts, but that stress also makes it tough to solve more complex problems.  more

Breast cancer risk, prognosis and weight gain reduced with physical activity
Designing physical activity programs and interventions geared to breast cancer survivors will increase well-being and may improve prognosis, Yale researchers report in a recent issue of Medicine and Science in Sports and Exercise. more

Human embryonic stem cells promising for replacement of blood supply
Researchers at the University of Minnesota Stem Cell Institute are one step closer to understanding how blood cells develop through the use of human embryonic stem cells. The research better defines the conditions under which blood cell development occurs, making the process easier to replicate. The findings are published in the October issue of Experimental Hematology. more

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