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Two-stage weight loss surgery for high-risk, morbidly obese patients reduces surgical risk
A staged approach to Roux-en-Y gastric bypass surgery, in which high-risk, morbidly obese patients first undergo a procedure called laparoscopic sleeve gastrectomy (LSG), greatly reduces operative risk and results in significant short-term weight loss, according to a University of Pittsburgh study presented today at the annual meeting of the Society of American Gastrointestinal Endoscopic Surgeons in Denver.
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New information about heart enzymes could lead to better treatments
New evidence in animals about hormones that regulate blood pressure and heart function could lead to better treatments for humans after heart attacks, say researchers from Wake Forest University Baptist Medical Center. more
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Monitoring macrophages detects dementia
HIV-associated dementia complex, termed HIV encephalitis, occurs in about one-quarter of infected individuals. Unfortunately, the symptoms and signs of dementia are not usually evident until the late stages of encephalitis, after irreversible damage has occurred. Thus, diagnostic tools for the detection of HIV encephalitis prior to the manifestation of neurological signs would greatly aid in developing therapeutic intervention. more
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The biology of fear
New findings at the UCLA Neuropsychiatric Institute demonstrate the potential of a substance found in yohimbe tree bark to accelerate recovery from anxiety disorders suffered by millions of Americans.
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VEGF-A versatility
Lymphangiogenesis and hemangiogenesis are both important processes in angiogenesis, which plays a central role in tumor progression, chronic inflammatory disorders, and most blinding ocular diseases. The VEGF family of growth factors is a key contributor to these processes. more
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Overcoming obstacles in antiangiogenesis gene therapy
Antiangiogenic gene therapy strategies against cancer are considered preferable to direct tumor-targeting strategies because tumor cells, with their high somatic mutation frequency, often develop resistance to apoptotic stimuli. Gene therapy in the vasculature, however, also has limitations, including lack of expression specificity and loss of transgene expression due to the body's immune response. more
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Possibilities from the impossible in leukemia patients
The chance finding of a common rearrangement in the variable region of an immunoglobin (Ig) receptor in different individuals is staggeringly unlikely: Ig genes can potentially create over 3.4 million functional rearrangements. more
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