Volume 7 Issue 112
Published - 14:00 UTC 08:00 EST 22-Apr-2005 
Next Update - 14:00 UTC 08:00 EST 23-Apr-2005

Editor: Susan K. Boyer, RN
© Vidyya.
All rights reserved.



Metabolic syndrome, weight control problems linked to body clock

A new mouse study suggests that a brain system that controls the sleep/wake cycle might also play a role in regulating appetite and metabolism. Mice with a mutation in a gene called "Clock," which helps drive circadian rhythm, ate significantly more and gained more weight. The finding could help explain why disrupted sleep patterns — particularly when combined with a high-fat diet — are associated with excessive weight gain and the onset of metabolic syndrome in some people, according to investigators supported by the National Institutes of Health (NIH). more  

Heart failure drug associated with higher risk of death in first month

A drug that helps heart failure patients survive a crisis may actually increase their risk of dying in the first month after they leave the hospital, according to a new study that will be published April 20 in the Journal of the American Medical Association. more

Prescribing information: NATRECOR® (nesiritide)

Natrecor® (nesiritide) is the first therapy approved for the treatment of acute congestive heart failure since 1987. Research published this month in JAMA shows that patients receiving this drug are 80 percent more likely to die in the next month than patients who received traditional drugs for acute heart failure symptoms. more  

Strongest proof yet found for prion hypothesis

UTMB scientists offer strongest evidence yet that infectious misformed proteins cause mad cow disease and other mysterious brain disorders. more

Genes influence how heart failure patients respond to drugs  

Genes dictate the color of our hair and eyes. They factor into whether we get cancer or heart disease. And, scientists increasingly recognize, they also ensure some patients will benefit from a prescription drug, while others develop adverse reactions or simply fail to respond at all. more

Molecule on immune cells linked to sexual transmission of HIV  

Scientists have long suspected that HIV hijacks immune cells called dendritic cells to infiltrate the immune system. Now UCLA AIDS Institute researchers have shown that blocking HIV's access to a naturally occurring molecule on dendritic cells may cut their ability to smuggle the virus into other immune cells. Published in the May edition of the Journal of Virology, the discovery may lead to new drugs to prevent sexually transmitted HIV infection. more

Method holds promise in identifying markers of non-metastatic vs. metastatic breast cancer

Researchers at the University of California, San Diego have used a new strategy to identify differences between non-metastatic and highly metastatic breast cancer cells. The article by Valerie Montel et al., "Expression profiling of primary tumors and matched lymphatic and lung metastases in a xenogeneic breast cancer model," appears in the May 2005 issue of The American Journal of Pathology and is accompanied by a commentary. more


A study in JAMA shows that patients receiving nesiritide are more likely to die in the next month than patients who received traditional drugs for acute heart failure symptoms