Vidyya Medical News Service
Volume 7 Issue 18 Published - 14:00 UTC 08:00 EST 18-Jan-2005 Next Update - 14:00 UTC 08:00 EST 19-Jan-2005
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Grapefruit juice and medication can be a deadly mix
Interactions between grapefruit juice and medications have long been recognized. Last year, the Medical Letter on Drugs and Therapeutics devoted an entire issue to grapefruit juice and the dangerous drug interactions that can result. The U.S. Food & Drug Administration requires all prospective new drugs to be tested for interactions with grapefruit juice. And a warning about grapefruit juice is included in the "food-drug interactions" that come with dozens of medications. (Article includes list of medications that interact with grapefruit juice.)  more

Penn researchers add more evidence to demonstrate role of COX inhibitors in heart-disease risk
In two articles, published in Circulation, researchers from the University of Pennsylvania School of Medicine provide further evidence for the role of cyclooxygenases (COX) in heart-disease risk. In one, a statistical meta-analysis of two placebo-controlled trials, the COX-2 inhibitor Bextra elevated the combined incidence of heart attack and stroke three-fold in coronary artery bypass graft (CABG) surgery patients. In the second, the investigators found that a fat produced by COX-1 speeds hardening of the arteries in a mouse model of atherosclerosis, which may have implications for low-dose aspirin therapy in heart patients.  more

Scientists detect probable genetic cause of some Parkinson's disease cases
Two new studies strongly suggest that a mutation in a recently discovered gene is the most common genetic cause of Parkinson's disease identified to date. The discovery by an international research team provides fresh evidence that genetics may contribute to the development of some cases of Parkinson's disease. The findings could lead to the development of a genetic test to detect the mutation in individuals at risk.  more


Cancer vaccines: A two-pronged attack?
The latest findings in cancer vaccine development suggest that cancer vaccines may have two modes of action; specific immunization and non-specific activation of immune cells paralyzed by the tumor.  more

Individualized medicine emerging from gene-environment studies
New understanding of the dynamic interplay between genes and environment, made possible by technologies arising from the Human Genome Project, helps support the individualization of medicine and makes focusing on racial or ethnic group differences in disease less relevant, say Penn State researchers.  more

Colorectal cancer screening among adults aged 50 or older: Implementation of fecal occult blood testing in clinical practice
Colorectal cancer (CRC) is second only to lung cancer as the leading cause of cancer-related death in the United States. In 2004, itís estimated that CRC caused nearly 57, 000 deaths. more

Information for professionals: Health professionals facts on colorectal cancer screening
The natural history of CRC makes it ideally suited to screening. Most cancers develop over many years from benign adenomatous polyps. Precancerous polyps can be detected and removed during certain screening procedures, thereby preventing colorectal cancer. And when CRC is found early and appropriately treated, survival is greatly enhanced, with a 5-year relative survival rate of 90%. Currently only 37% of colorectal cancers are diagnosed at an early stage. more

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