Study finds flaws in cancer clinical trials
Cancer research and drug development are yielding more sophisticated candidate therapies, but investigators' methods to test them haven't kept pace, according to researchers at Memorial Sloan-Kettering Cancer Center. That could explain why so many experimental drugs fail in the final large and costly phase of testing, they say.
Genetic fingerprints identify brain tumors' origins
Genetic fingerprints that reveal where a brain cell came from remain distinct even after the cell becomes a brain tumor, an international coalition of scientists will report in the February 1 issue of Cancer Research. more
Study tests oral insulin to prevent type 1 diabetes
Researchers have begun a clinical study of oral insulin to prevent or delay type 1 diabetes in at-risk people, the National Institutes of Health (NIH) announced today. Type 1 Diabetes TrialNet, an NIH-funded network of researchers dedicated to the understanding, prevention, and early treatment of type 1 diabetes, is conducting the study in more than 100 medical centers across the United States, Canada, Europe, and Australia. more
Stanford-led study closes in on genes that may predispose some people to severe depression
Some people appear to be genetically predisposed to developing severe depression, but researchers have yet to pin down the genes responsible. Now, a specific region rife with promise has been located on one chromosome by a consortium of researchers working under Douglas Levinson, MD, professor of psychiatry and behavioral sciences at the Stanford University School of Medicine. more
Extreme irritability -- is it childhood bipolar disorder?
Results of a new study may help improve the diagnosis and treatment of two debilitating childhood mental disorders -- pediatric bipolar disorder (BD) and a syndrome called severe mood dysregulation (SMD). When the brain's electrical signals were measured during mildly frustrating situations, researchers from the National Institute of Mental Health (NIMH), of the National Institutes of Health, found a very different pattern in children with SMD, compared with children who had BD. The results indicate that different brain mechanisms may lead to irritability in children with SMD, suggesting that they may have an illness other than BD and may require different treatments.
Peptide vaccine fights off breast tumors with aid of bacteria-mimicking agents
With the help of immune system-stimulating molecules that mimic bacterial components, researchers have used a type of cancer vaccine to both delay and prevent breast tumors in mice. The strategy, they say, holds promise for the future use of peptide vaccines in women who are at high risk for developing breast cancer. more
New compound shows promise in halting HIV spread
A new compound has shown promise in halting the spread of HIV by preventing the virus from replicating. Developed by Temple University researchers, 2-5AN6B could someday work as an effective treatment for HIV especially in conjunction with current drug treatments. Their work is published in the January issue of AIDS Research and Human Retroviruses. more
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