Hormone therapy may confer more aggressive properties to prostate tumors
(10 June 2009: VIDYYA MEDICAL NEWS SERVICE) -- Hormone therapy is often given to patients with advanced prostate cancer. While it is true that the treatment prevents growth of the tumor, it also changes its properties. Some of these changes may result in the tumor becoming more aggressive and more liable to form metastases. This is one of the conclusion of a thesis presented at the Sahlgrenska Academy.
Hormone therapy has serious side effects and is therefore used only when the tumor has grown too large to be treated in any other way, or when the tumor has spread and formed metastases. The hormone that is given causes the natural production of male sex hormone to fall, and the tumor stops growing. Pain also usually decreases.
"Our results suggest that the tumor properties change following hormone therapy such that the tumors at a later stage can continue to grow and spread in the body. For this reason, it is probably necessary to supplement the hormone therapy in order to compensate for these changes", says pharmacist Karin Jennbacken, author of the thesis.
The results show that patients who have been given hormone therapy have higher levels of the proteins that enable the cancer cells to move through the body and attach to other organs. One of these proteins is known as "N-cadherin", and this protein is present in higher levels in patients who have been given hormone therapy.
"We don't have any good treatment alternatives in cases where the tumor returns after hormone therapy, and this means that it is particularly important to study how such tumors are controlled and how they behave. The properties that we have identified may become targets for new anti-metastatic drugs in advanced prostate cancer", says Karin Jennbacken.
Approximately 9,000 new cases of prostate cancer are diagnosed each year in Sweden, making it the most common of all cancer forms. Many of the tumors grow very slowly and give no symptoms, but prostate cancer can also display a more aggressive course, spreading metastases to lymph nodes, the skeleton and other locations. The complete prostate is often surgically removed if the cancer is diagnosed early. Other treatments available are radiation therapy and hormone therapy.
A thesis presented for the degree of Doctor of Philosophy (Medicine) at the Sahlgrenska Academy, Institute of Clinical Sciences, Department of Urology.
Title of the thesis: Invasive and metastatic properties of advanced prostate cancer.
BY: Elin Lindström Claessen
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