Volume 11 Issue 183
Published - 14:00 UTC 08:00 EST 15-Jul-2009 
Next Update - 14:00 UC 08:00 EST 16-Jul-2009

Editor: Susan K. Boyer, RN
Vidyya.
All rights reserved.




  

 




Fighting drug-resistant flu viruses 

(15 July 2009: VIDYYA MEDICAL NEWS SERVICE) -- Amid reports that swine flu viruses are developing the ability to shrug off existing antiviral drugs, scientists in Japan are reporting a first-of-its kind discovery that could foster a new genre of antivirals that sidestep resistance problems, according to an article scheduled for the July 23 issue of the ACS' Journal of the Medicinal Chemistry, a bi-weekly publication.

Toshinori Sato and colleagues note in the new study that current antiviral drugs, including Tamiflu and Relenza, fight influenza by blocking key proteins that viruses need to reproduce. As the viruses reproduce, however, they can mutate into drug-resistant strains.

The researchers describe discovery of a new way to prevent flu viruses from infecting cells in the first place. They identified potential drugs that can block the first step in the infection process, and demonstrated that the substances work in cell cultures. "These results may lead to a new approach in the design of antiviral drugs," they state, noting that it could be used to develop new drugs for a variety of other medical problems.

"Inhibition of Influenza Virus Infections by Sialylgalactose-Binding Peptides Selected from a Phage Library"

http://pubs.acs.org/stoken/presspac/presspac/full/10.1021/jm801570y

Return to Vidyya Medical News Service for 15 July 2009

© Vidyya. All rights reserved.

Information appearing on the Vidyya Medical News Service is not intended as a substitute for professional medical care. Seek professional medical help and follow your health care provider's advice.

Interested in subscribing to our daily e-mail newsletter? Send an email to Vidyya@vidyya.com with the word subscribe in the subject field.