Vidyya Medical News Service
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Volume 6 Issue 300 Published - 14:00 UTC 08:00 EST 26-Oct-2004 Next Update - 14:00 UTC 08:00 EST 27-Oct-2004
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New oral vaccine for Alzheimer's disease

Alzheimer's disease is characterized by progressive loss of cognitive function due to amyloid-beta (Aß) deposits in the central nervous system. If these deposits could be stopped or slowed, Alzheimer's disease might become more manageable. In the current issue of the Journal of Alzheimer's Disease, a novel paper from researchers from the National Institute for Longevity Sciences, NCGG, Japan and Center for Neurological Diseases, Brigham & Women's Hospital, Harvard Institute of Medicine shows that a new oral vaccine treatment is effective in reducing Alzheimer's disease pathology.

Immunization results from the production of antibodies which attack the harmful agent, using the body's own defenses to remove the threat. In an earlier immunization study, 6 percent of the subjects developed acute meningoencephalitis, most likely caused by autoimmune T-cell activation. This caused the trial to be stopped. By developing vaccines that can minimize this T-cell activation while retaining the production of Aß-antibodies, a safer treatment might result.

The researchers attached Aß DNA to an adeno-associated virus vector and administered this vaccine to mice orally. Not only were the Aß levels decreased, but the T-cell immune response was significantly reduced. A single dose of this vaccine enhanced the production of Aß-antibodies for more than 6 months. Immunohistochemistry of the mouse brain tissue showed that the extra-cellular amyloid deposits were clearly decreased compared to the non-treated mouse.

Hideo Hara, M.D, writes "This new oral vaccine does not induce strong T cell immune reactions, and hence it could reduce the side effect of such meningoencephalitis…This new therapy seems to be effective for prevention and treatment of Alzheimer's disease."

The article is "Development of a safe oral Aß vaccine using recombinant adeno-associated virus vector for Alzheimer's disease" by Hideo Hara, Alon Monsonego, Katsutoshi Yuasa, Kayo Adachi, Xiao Xiao, Shin'ichi Takeda, Keikichi Takahashi, Howard L. Weiner and Takeshi Tabira. It appears in the Journal of Alzheimer's Disease, Vol.6, Number 5, published by IOS Press.



Additional Vidyya Resources:

   Alzheimer's Disease  
   Alzheimer's Disease And Dementia: Reminyl (Galantamine Hydrobromide)  
   Alzheimer's Disease Fact Sheet  
   Alzheimer's disease genetics fact sheet   
   Alzheimer's disease - Unraveling the mystery  
   Forgetfulness: It’s Not Always What You Think  
   Alzheimer's Disease: Unraveling the Mystery  
   New Fronts in Alzheimer's Research  
   Alzheimer's Disease Info: Questions to Ask the Doctor (Administration on Aging)   
   Mild Cognitive Impairment: Possible Predictor of Alzheimer's (Mayo Foundation for Medical Education and Research)  
   Agitation and Alzheimer's Disease (Alzheimer's Association) - Links to PDF File   
   Depression and Alzheimer's Disease (American Academy of Family Physicians)   
   Sleep Changes in Alzheimer's Disease (Alzheimer's Association) - Links to PDF File   
   Alzheimer's Disease Medications (National Institute on Aging)  
   Coping with Changes in Daily Life (Alzheimer's Association)   
   Helping Your Family and Friends (Alzheimer's Association)   
   Making Job Decisions (Alzheimer's Association)   
   Aluminum and Alzheimer's Disease (Alzheimer's Association) - Links to PDF File  
   Choosing Health Care Providers and Facilities (Alzheimer's Association)   
   Financial Matters for Alzheimer's Care (Alzheimer's Association)  
   Alzheimer's Disease Education and Referral (ADEAR) Center (National Institute on Aging)   
   Alzheimer's Association  
   Administration on Aging   
   Fisher Center for Alzheimer's Research Foundation   

News Articles:

   Alzheimer's: Searching for a cure -19-August-2003   
   Antibiotic therapy for Alzheimer's? -10-October-2003   
   Anti-inflammatory drugs lower risk of Alzheimer's -18-July-2003  
   Brain plaques in Alzheimer’s disease linked to eye disease -11-May-2003  
   Can vitamins slow the progression of Alzheimer’s disease? -16-March-2003  
   Drug Improves Brain Structure in Alzheimer's Patients -03-November-2003  
   Enzyme helps guard against Alzheimer's disease -31-July-2003  
   Enzyme reponsible for Alzheimer's plaques blocked by lithium. -22-May-2003  
   FDA approves memantine (Namenda) for Alzheimer's disease -18-October-2003   
   Findings reported in February Archives of Neurology provide new insights on Alzheimer’s disease -19-February-2003   
   First study of Alzheimer's caregivers and end-of-life cites both remarkable resilience, need for support -14-November-2003  
   Information from the FDA: Alzheimer's --- Searching for a cure -22-July-2003  
   Leisure activity may reduce risk of Alzheimer's -21-October-2003  
   Neuroscientists pinpoint midlife crisis in brain circuitry as key to brain aging and onset of Alzheimer's later in life -30-December-2003  
   A new molecular culprit for type II diabetes, Alzheimer's and Parkinson's -22-October-2003   
   New studies in mice suggest ways to clear damaging Alzheimer’s amyloid plaques -26-May-2003   
   Rush researchers find effects of Alzheimer's disease may be influenced by education -25-June-2003  
   Searching for 1,000 families with multiple members with Alzheimer's disease -26-July-2003  
   Stroke may increase risk of Alzheimer disease -16-December-2003  
   Study boosts confidence in potential screening tool for Alzheimer's disease Lifestyle changes effective in lowering blood pressure -24-April-2003   
   Study boosts confidence in potential screening tool for Alzheimer's disease -02-May-2003  
   Study shows people with Alzheimer's can benefit from exercise combined with caregiver training -15-October-2003  
   Study suggests dramatically rising numbers of people with Alzheimer’s disease -19-August-2003   
   Synthetic marijuana reduces agitation in patients with Alzheimer’s -16-November-2003  
   3-D images show how Alzheimer's engulfs brain -09-February-2003   
   Two new studies showed Alzheimer’s disease treatment beneficial in other memory-related conditions -06-April-2003  
   UCLA researcher discovers the role of common painkillers in protecting against Alzheimer's disease -13-March-2003  
   Unusual form of memory loss often confused for Alzheimer's disease -20-October-2003  
   Additional information: Low free testosterone levels linked to Alzheimer’s disease in older men -30-January-2004  
   Alzheimer’s Association statement on a study of clioquinol targeting Aß amyloid deposition and toxicity in alzheimer’s disease from Archives Of Neurology, December 2003 -05-January-2004   
   Brain cell death in Alzheimer’s disease linked to protein accumulation and insulin biochemistry -22-June-2004  
   Brightly colored cups, plates spur food, beverage consumption in advanced Alzheimer's disease -25-September-2004  
   Diabetes linked to increased risk of Alzheimer's in long-term study -22-May-2004  
   Diagnosticians would do well to raise the bar when testing high-functioning people for pre-clinical signs of Alzheimer's disease -05-January-2004  
   Immunoglobulin therapy for Alzheimer's? -18-September-2004  
   The mentally-demanding job and development of Alzheimer's disease -10-August-2004  
   New animal model for Alzheimer vaccine -07-March-2004  
   New research may explain how fats damage neurons in Alzheimer's patients and how diet, hormones and exercise might delay disease onset -16-February-2004  
   New study supports use of PET scans in early diagnosis of Alzheimer’s disease -12-March-2004  
   No clear-cut answers on statins as therapy for Alzheimer's disease -19-July-2004  
   Pharmaceutical "metal binder" could put the breaks on Alzheimer symptoms -05-January-2004  
   Study is another step in determining if curry can protect against Alzheimer's -19-April-2004  
   Study: Distress-prone people more likely to develop Alzheimer's disease -19-January-2004  
   Study identifies predictors of Alzheimer's disease longevity -8-April-2004  
   Study suggests antipsychotics do not raise risk of stroke in Alzheimer's patients -23-July-2004  
   TANGO towards faster prognosis of Alzheimer's and Parkinson's diseases? -14-September-2004  
   Two proteins may help prevent Alzheimer's brain plaques -22-January-2004  
   Two studies examine relationship between Alzheimer's disease and testosterone -27-January-2004   
   2001-2002 Progress report on Alzheimer's disease -19-January-2004  
   Vitamin supplement use may reduce effects of Alzheimer's disease -20-January-2004  
   When should early-Alzheimer's patients stop driving? Visuospatial tests best predictors of driving skill -26-January-2004   


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