Myeloid leukemia linked to body size
(13 August 2005: VIDYYA MEDICAL NEWS SERVICE) -- The risk of myeloid leukemia is associated with body size and composition, according to a study in the August 3 JNCI.
The Melbourne Collaborative Cohort Study involved 40,909 people in Australia, and explored the correlation between nutritional and lifestyle choices and cancer. Beginning in 1990, participants between the ages of 27 and 75 were followed for an average of 8.4 years. Height, weight, and waist and hip circumferences were measured and used to compute body mass index (BMI), waist-to-hip ratios, fat mass, and percent fat. The researchers also collected information on country of birth, alcohol consumption, smoking, physical activity, and education level.
The report found that myeloid leukemia is linked to several components of body size. Overweight and obese persons (those with a BMI of at least 25 and 30, respectively) were 5 times more likely to have myeloid leukemia than those with BMIs lower than 25. Waist circumference was related to increased risk as well. Stature was not linked to myeloid leukemia incidence; however, people with a higher non-fat component of weight or central adiposity were at an increased risk.
Conversely, other lymphohematopoietic malignancies - including non-Hodgkin's lymphoma, multiple myeloma, and lymphocytic leukemia - showed little relation to body size. However, lead author Dr. Graham G. Giles noted that past research on these relationships has been minimal, and some reports have found obese people at increased risk for these diseases, so whether an association exists remains unclear.
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