Vidyya Medical News Service
Volume 7 Issue 7 Published - 14:00 UTC 08:00 EST 7-Jan-2005 Next Update - 14:00 UTC 08:00 EST 8-Jan-2005
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HRT associated with increased risk of stroke

(7 January 2005: VIDYYA MEDICAL NEWS SERVICE) -- A review of published clinical trials reaffirms the link between hormone replacement therapy (HRT) and an increased risk of stroke, especially ischemic stroke. The review of HRT and stroke was published this week on on

These results support previous trials that have suggested a link between HRT and stroke.

Researchers at the University of Nottingham reviewed the evidence from 28 completed trials involving 39,769 individuals. They assessed the risk of stroke by type, severity, and outcome.

Hormone replacement therapy was associated with an overall 29% increase in the risk of stroke, especially ischaemic stroke (caused by an insufficient blood supply to the brain). The severity of stroke was also increased with hormone replacement therapy.

It remains unclear why HRT should increase ischaemic stroke and its severity when some previous studies have suggested it might have a protective effect, say the authors. However, given these findings, HRT cannot be recommended for the primary or secondary prevention of stroke.

Association between hormone replacement therapy and subsequent stroke: a meta-analysis BMJ Online First

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